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The HMGCR genetic variant might be associated with risks of prostate and breast cancers. HMGCR - 3-hydroxy-3-methylglutaryl-CoA reductase (human) HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase) is a Protein Coding gene. Diseases associated with HMGCR include Familial Hyperlipidemia and Sitosterolemia. Among its related pathways are Sterol Regulatory Element-Binding Proteins (SREBP) signalling and Regulation of cholesterol biosynthesis by SREBP (SREBF). Cholesterol synthesis was blocked in culture by inhibiting the activity of HMG CoA reductase (HMGCR) resulting in germ cell survival and migration defects renal ischemia/reperfusion activates the HMGCR gene via multiple stress-activated transcriptional and epigenetic pathways, contributing to renal cholesterol loading. R-HSA-191273, Cholesterol biosynthesis R-HSA-1989781, PPARA activates gene expression R-HSA-2426168, Activation of gene expression by SREBF (SREBP) R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination: SABIO-RK i: P04035 HMGCR gene expression in Bgee. Bgee allows to automatically compare gene expression patterns between species, by referencing expression data on anatomical ontologies, and designing homology relationships between them.
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Description. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the … The gene view histogram is a graphical view of mutations across HMGCR. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the p Search external sites for HMGCR 2021-04-06 Gene ID: Human(3156) Summary: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol … 2012-09-18 2012-10-03 Gene information about ENSG00000113161 / HMGCR - 3-hydroxy-3-methylglutaryl-CoA reductase Blood lipid genetic scores, the HMGCR gene and cancer risk : A Mendelian randomization study.
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2467 individuals in the general population-based EpiHealth. study .
Anti-HMGCR myopathy may resemble limb-girdle muscular
Government Organization · Human Heredity and Health in Africa - H3Africa · Professional Society of Genetic We evaluated the association of a single nucleotide polymorphism (rs17238540) in the HMGCR gene with lipid-lowering response to statins in a large We also investigated cancer risk for a SNP (rs12916) in the gene encoding hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the av P Mohassel · 2019 · Citerat av 19 — Patients with presumed LGMD and unrevealing genetic testing were selected based on a few clinico-pathologic features and tested for anti- Variants in the HMGCR gene region, which represent proxies for statin treatment, were associated with overall cancer risk (odds ratio [OR] per one standard Variations in genes associated with cholesterol homeostasis have been CoA reductase (HMGCR) gene promoter on basal and regulated transcription, We aim to study the role of the obesity-linked gene and statin target HMGCR in endocrine, neuronal and muscular functions. We discovered that Hmgcr HMGCR Antibody (H-300) has been replaced by a more specific monoclonal antibody, HMGCR (C-1) that provides a stronger signal & more reproducible data.
21 Aug 2019 Regulatory mechanism of HMGCR. The human HMGCR gene (GeneID: 3156) is located on chromosome 5q12, and it encodes three isoforms (
1 Sep 2011 Background and objectives Experimental acute kidney injury (AKI) activates the HMG–CoA reductase (HMGCR) gene, producing proximal tubule
13 Sep 2016 Similarly, using RT-qPCR, the statin-induced feedback up-regulation of four selected cholesterol biosynthesis genes (HMGCR, HMGCS1, MVD
3-hydroxy-3-methylglutaryl-CoA reductase. Target Gene.
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Data show that 12 SNPs from CETP, APOAI, ABCB1, CYP7A1, and HMGCR genes to be associated with baseline LDL-C and high-density lipoprotein cholesterol levels and increased risk of CAD. Peroxisomal HMGCR might be coded by a second gene, but is not detected because it is more than 35% different from the ER enzyme. This is confuted by the fact that peroxisomal HMGCR is recognized not only in the catalytic domain but also at epitopes in the membrane-spanning region by several of the same antibodies as the ER enzyme. HMGCR: Description: 3-hydroxy-3-methylglutaryl-CoA reductase [Source:HGNC Symbol;Acc:HGNC:5006] Organism: Homo sapiens: Synonym(s) b7z3y9, ldlcq3, q8n190 However, gene encoding HMGCR remains unchanged regardless of the type of dietary feeding assays.
Blood lipid genetic scores, the HMGCR gene and cancer risk: A Mendelian randomization study. International Journal of Epidemiology, 47(2), 495-505. Use Bio-Rad's PrimePCR assays, controls, templates for your target gene.
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As in the hamster Hmgcr gene, this upstream region provides sites for statin-dependent induction and sterol-dependent suppression. Gene: Hmgcr - ENSMUSG00000021670 - Mus musculus (mouse) General information. Ensembl ID: ENSMUSG00000021670: Name: Hmgcr: Description Symbol Description Category GIFtS GC id Score; 1: HMGCR: 3-Hydroxy-3-Methylglutaryl-CoA Reductase: Protein Coding: 47: GC05P075336: 47.16: 2: PRKAA2: Protein Kinase AMP-Activated Catalytic Subunit Alpha 2 Searching the mammalian genome databases with the protein sequence of human HMGCR revealed only a single HMGCR gene in all three genomes, i.e., only a single gene with a statistically significant similarity to the catalytic domain of HMGCR (TBLASTN E-score < 0.001). The human gene is localized at 5q13.3-q14.3 and the rodent homologs are found Previous studies in cultured cells (Schumacher et al., 2015) revealed that UBIAD1 also inhibits endoplasmic reticulum (ER)-associated degradation (ERAD) of ubiquitinated HMG CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway that produces cholesterol and essential nonsterol isoprenoids. HMGCR protein and Hmgcr mRNA levels of DMSO-treated cells were defined as 1. Glyceraldehyde-3-phosphate dehydrogenase ( Gapdh ) was a reference gene. f , g SRD-13A cells were treated with However, gene encoding HMGCR remains unchanged regardless of the type of dietary feeding assays.
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The study investigated cancer risk for a single-nucleotide polymorphisms (SNP rs12916) in the gene encoding hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the targeted enzyme in statin treatment. The HMGCR genetic variant might be associated with risks of prostate and breast cancers.
Every primer pair is optimized, experimentally validated, and performance guaranteed. HMGCR - PrimePCR Assay and Template | Life Science | Bio-Rad Blood lipid genetic scores, the HMGCR gene and cancer risk: A Mendelian randomization study. International Journal of Epidemiology, 47(2), 495-505. Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. Summaries for HMGCR gene (According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL) About This Sectio Gene name. HMGCR : Synonyms. Description.